Search results
Results from the WOW.Com Content Network
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
SIRT1 binds and activates PGC-1α through deacetylation inducing gluconeogenesis without affecting mitochondrial biogenesis. [20] PGC-1α has been shown to exert positive feedback circuits on some of its upstream regulators: PGC-1α increases Akt (PKB) and Phospho-Akt (Ser 473 and Thr 308) levels in muscle. [21] PGC-1α leads to calcineurin ...
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
SRT-1720 is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and efficacy in humans have not been established.
Almost seven years since health officials tied a huge listeriosis outbreak to products made by South Africa’s Tiger Brands, alleged victims are still awaiting compensation.
After our tour, we dined onsite at the STATE Grill and Bar, where the cameras and Casey’s acrophobia faded away.I felt like we had such an honest conversation, touching on lighter and more ...
Climate change will wipe out about $1.47 trillion in U.S. home values over the next three decades and hasten economic gaps in U.S. communities, a report released on Monday finds.