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Citrate synthase (E.C. 2.3.3.1 (previously 4.1.3.7)) is an enzyme that exists in nearly all living cells. It functions as a pace-making enzyme in the first step of the citric acid cycle (or Krebs cycle). [5] Citrate synthase is located within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than
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In enzymology, a homocitrate synthase (EC 2.3.3.14) is an enzyme that catalyzes the chemical reaction acetyl-CoA + H 2 O + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
In molecular biology, the citrate synthase family of proteins includes the enzymes citrate synthase EC 2.3.3.1, and the related enzymes 2-methylcitrate synthase EC 2.3.3.5 and ATP citrate lyase EC 2.3.3.8. Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion ...
The mammalian ATP citrate lyase has a N-terminal citrate-binding domain that adopts a Rossmann fold, followed by a CoA binding domain and CoA-ligase domain and finally a C-terminal citrate synthase domain. The cleft between the CoA binding and citrate synthase domains forms the active site of the enzyme, where both citrate and acetyl-coenzyme A ...
In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction acetyl-CoA + H 2 O + oxaloacetate ⇌ {\displaystyle \rightleftharpoons } citrate + CoA The 3 substrates of this enzyme are acetyl-CoA , H 2 O , and oxaloacetate , whereas its two products are citrate and CoA .
The systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase , citratase , citritase , citridesmolase , citrate aldolase , citric aldolase , citrate lyase , citrate oxaloacetate-lyase , and citrate oxaloacetate-lyase [(pro-3S ...
In enzymology, a 2-methylcitrate synthase (EC 2.3.3.5) is an enzyme that catalyzes the chemical reaction propanoyl-CoA + H 2 O + oxaloacetate ⇌ {\displaystyle \rightleftharpoons } (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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