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B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. [1] They function in the humoral immunity component of the adaptive immune system. [1] B cells produce antibody molecules which may be either secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors. [2]
Memory B cells that lack CD27 are generally associated with exhausted B cells or certain autoimmune conditions such as HIV, lupus, or rheumatoid arthritis. [2] [3] Because B cells have typically undergone class switching, they can express a range of immunoglobulin molecules. Some specific attributes of particular immunoglobulin molecules are ...
A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. [1] Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive immunity), [2] [3] and innate lymphoid cells (ILCs; "innate T cell-like" cells involved in mucosal immunity and homeostasis), of which natural killer cells are an ...
These cells have T-cell receptors and CD4 molecules that, in combination, bind antigenic peptides presented on major histocompatibility complex (MHC) class II molecules on antigen-presenting cells. Helper T cells make cytokines and perform other functions that help coordinate the immune response .
BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell. Differentiation factors control cell fate and can sometimes ...
In mice, MZ B cells characteristically express high levels of CD1d, which is an MHC class I-like molecule involved in the presentation of lipid molecules to NKT cells. [8] Unlike FO B cells, MZ B cells express polyreactive BCRs that bind to multiple microbial molecular patterns. Additionally, they express high levels of TLRs. [2]
Dust cell; 20-21 Carbon debris from lungs; General macrophage targets [8] Dendritic cell: Monocyte: Dendritic cell: DC; Cellula dendritiformis; 10-15 Process antigen material and present to the T cell; Messengers between innate and adaptive immune system [12] [13] B cell: Lymphocyte: B cell: B lymphocyte; Lymphocytus B; 8-10 Produces antibody ...
In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils , spleen , and primary lymphoid follicles in lymph nodes . Once exposed to an antigen , the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound.