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•List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol. Follow the Python code link for information about updates to the list of genes on these pages.
Cycle (cyc) is a gene in Drosophila melanogaster that encodes the CYCLE protein (CYC). The Cycle gene ( c yc) is expressed in a variety of cell types in a circadian manner. It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism.
•List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol. Follow the Python code link for information about updates to the list of genes on these pages.
Fig. 1 The diagram shows the role of Cdk1 in progression through the S. cerevisiae cell cycle. Cln3-Cdk1 leads to Cln1,2-Cdk1 activity, eventually resulting in Clb5,6-Cdk1 activity and then Clb1-4-Cdk1 activity. [5] When bound to its cyclin partners, Cdk1 phosphorylation leads to cell cycle progression.
Activators such as E2F1, E2F2, E2F3a promote and help carryout the cell cycle, while repressors inhibit the cell cycle. Yet, both sets of E2F have similar domains. E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or DP2, proteins distantly related to E2F.
The CDK4 gene is located on chromosome 12 in humans. [7] The gene is composed of 4,583 base pairs which together code for the 303 amino acid protein with a molecular mass of 33,730 Da. [7] [8] All CDK proteins, including CDK4, have two lobes: the smaller N-terminal lobe (which contains an inhibitory G-loop), and the C terminal lobe (which contains an activation domain and a T-loop).
A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. [8] [9] [10] Loss of p27 expression has been observed in metastatic canine mammary carcinomas. [11] [12] [13] Decreased TGF-beta signalling has been suggested to cause loss of p27 expression in this tumor type. [14]
904 12455 Ensembl ENSG00000129315 ENSMUSG00000011960 UniProt O60563 Q9QWV9 RefSeq (mRNA) NM_001240 NM_001277842 NM_009833 NM_001368702 RefSeq (protein) NP_001231 NP_001264771 NP_033963 NP_001355631 Location (UCSC) Chr 12: 48.69 – 48.72 Mb Chr 15: 98.44 – 98.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene ...