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Radioactive iodine (iodine-131) alone can potentially worsen thyrotoxicosis in the first few days after treatment. One side effect of treatment is an initial period of a few days of increased hyperthyroid symptoms. This occurs because when the radioactive iodine destroys the thyroid cells, they can release thyroid hormone into the blood stream.
Product labeling for diagnostic 131 I iobenguane recommends giving potassium iodide one day before injection and continuing 5 to 7 days following. [19] 131 I iobenguane used for therapeutic purposes requires a different pre-medication duration, beginning 24–48 hours before iobenguane injection and continuing 10–15 days after injection. [16]
Iodine is a chemical element with many uses in medicine, depending on the form. Elemental iodine and iodophors are topical antiseptics. [2] Iodine, in non-elemental form, functions as an essential nutrient in human biology (see iodine in biology). [3] Organic compounds containing iodine are also useful iodinated contrast agents in X-ray imaging ...
Iodine-124 can be made by numerous nuclear reactions via a cyclotron. The most common starting material used is 124 Te. Iodine-124 as the iodide salt can be used to directly image the thyroid using positron emission tomography (PET). [9] Iodine-124 can also be used as a PET radiotracer with a usefully longer half-life compared with fluorine-18 ...
Many of the side effects are due to the hyperosmolar solution being injected. i.e. they deliver more iodine atoms per molecule. The more iodine, the more "dense" the X-ray effect. [citation needed] Organic iodine molecules used for contrast include iohexol, iodixanol, and ioversol. Iodine-based contrast media used nowadays are water-soluble.
However, unlike the Plummer and Wolff-Chaikoff effects, the Jod-Basedow effect does not occur in persons with normal thyroid glands, as thyroid hormone synthesis and release in normal persons is controlled by pituitary TSH secretion, which does not allow hyperthyroidism when extra iodine is ingested. [citation needed]
Inadine is an iodine-containing non-sticky surgical dressing consisting of a knitted viscose fabric with a polyethylene glycol base that contains and slowly releases the antiseptic povidone-iodine (PVP-1). [1] [2] It is a topical wound dressing and is considered suitable for superficial wounds.
Tositumomab is a murine monoclonal antibody which targets the CD20 antigen produced in mammalian cell. [1] It was combined with iodine-131 to produce a radiopharmaceutical for unsealed source radiotherapy, Iodine-131 Tositumomab (branded as Bexxar), for the treatment of non-Hodgkins lymphoma. [1]