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Cystatin C is a non-glycosylated, basic protein (isoelectric point at pH 9.3). The crystal structure of cystatin C is characterized by a short alpha helix and a long alpha helix which lies across a large antiparallel, five-stranded beta sheet. Like other type 2 cystatins, it has two disulfide bonds.
Hereditary cystatin C amyloid angiopathy (HCCAA) is a rare, fatal type of hereditary cerebral amyloid angiopathy found almost exclusively in Iceland. A mutation in the protein cystatin C leads to amyloid (protein aggregate) dispositions in arteries in the brain, resulting in repeated brain hemorrhages .
n/a Ensembl ENSG00000170369 n/a UniProt P09228 n/a RefSeq (mRNA) NM_001322 n/a RefSeq (protein) NP_001313 n/a Location (UCSC) Chr 20: 23.82 – 23.83 Mb n/a PubMed search n/a Wikidata View/Edit Human Cystatin-SA is a protein that in humans is encoded by the CST2 gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active ...
These are cystatin-like proteins found in a range of organisms: plant phytocystatins, fetuin in mammals, insect cystatins, and a puff adder venom cystatin, which inhibits metalloproteases of the MEROPS peptidase family M12 (astacin/adamalysin). Also, a number of the cystatin-like proteins have been shown to be devoid of inhibitory activity.
This comparative procedure allowed the definition of a new type of kidney disorder characterized by a greater reduction of renal clearances of larger molecules (e.g. cystatin C, 13,343Da) than of smaller ones (e.g. creatinine, 113Da) and identified by a greater reduction of the cystatin C-based GFR-estimate (eGFR cystatin C) than that based ...
The functions of the kidney include maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.
1474 73720 Ensembl ENSG00000175315 ENSMUSG00000024846 UniProt Q15828 Q9D1B1 RefSeq (mRNA) NM_001323 NM_028623 RefSeq (protein) NP_001314 NP_082899 Location (UCSC) Chr 11: 66.01 – 66.01 Mb Chr 19: 5.39 – 5.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cystatin-M is a protein that in humans is encoded by the CST6 gene. The cystatin superfamily encompasses proteins that contain ...
228756 Ensembl ENSG00000125823 ENSMUSG00000055177 UniProt Q9H114 Q80Y72 RefSeq (mRNA) NM_138283 NM_177655 NM_001362207 RefSeq (protein) NP_612140 NP_808323 NP_001349136 Location (UCSC) Chr 20: 23.44 – 23.44 Mb Chr 2: 148.59 – 148.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cystatin-like 1 is a protein that in humans is encoded by the CSTL1 gene. The cystatin superfamily ...