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Laron syndrome (LS), also known as growth hormone insensitivity or growth hormone receptor deficiency (GHRD), is an autosomal recessive disorder characterized by a lack of insulin-like growth factor 1 (IGF-1; somatomedin-C) production in response to growth hormone (GH; hGH; somatotropin). [6]
NICE has recommended that somatropin hormone treatment may be given to a patient only if they meet three criteria; they have a severe growth hormone deficiency, they are already receiving full replacement with other deficient pituitary hormones as they need it and they have a score of at least 11 on the QoL-AGHDA.
Some cases are associated with a lack of other pituitary hormones, in which case it is known as combined pituitary hormone deficiency. [4] Diagnosis involves blood tests to measure growth hormone levels. [2] Treatment is by growth hormone replacement using synthetic human growth hormone. [1] The frequency of the condition is unclear. [2]
For example, a child who has a profound deficiency in growth hormone (especially if they are a cancer survivor with damage to the pituitary gland) may need to continue taking HGH as an adult ...
Several other hormones are responsible for modulating the body's response to insulin, including cortisol, growth hormone and sex hormones. Untreated or under-treated hormonal disorders such as adrenal insufficiency (see also Addison's disease [ 11 ] ) or growth hormone deficiency [ 12 ] can therefore sometimes cause insulin hypersensitivity ...
Growth hormone deficiency (GHD) is a medical condition in which the body produces insufficient growth hormone. Growth hormone, also called somatotropin, is a polypeptide hormone which stimulates growth and cell reproduction. If this hormone is lacking, stunted or even halted growth may become apparent. Children with this disorder may grow ...
Hypopituitarism specifically growth hormone deficiency has been reported as the only most common late morbidity of this treatment; GHD has been reported in 36% and 68% of the patients undergoing post-pituitary RT for Cushing's disease. [20]
Isolated growth hormone deficiency (IGHD) is a rare congenital disorder characterized by growth hormone deficiency and postnatal growth failure. [ 2 ] [ 3 ] It is divided into four subtypes that vary in terms of cause and clinical presentation.