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Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight). [ 2 ] [ 3 ] [ 4 ] Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 10 to 15 ...
Fluoride may also prevent cavities in adults of all ages. A 2007 meta-analysis by CDC researchers found that water fluoridation prevented an estimated 27% of cavities in adults, about the same fraction as prevented by exposure to any delivery method of fluoride (29% average). [58]
Topical fluorides are fluoride-containing drugs indicated in prevention and treatment of dental caries, particularly in children's primary dentitions. [1] The dental-protecting property of topical fluoride can be attributed to multiple mechanisms of action, including the promotion of remineralization of decalcified enamel, the inhibition of the cariogenic microbial metabolism in dental plaque ...
A U.S. government report expected to stir debate concluded that fluoride in drinking water at twice the recommended limit is linked with lower IQ in children. The report, based on an analysis of ...
Fluoride also has been added to oral care products such as toothpaste and mouth rinse.In 2015, U.S. health officials lowered the recommended amount of fluoride in drinking water to 0.7 milligrams ...
Fluoride toothpaste is the most widely used and rigorously evaluated fluoride treatment. [22] Its introduction is considered the main reason for the decline in tooth decay in industrialized countries, [3] and toothpaste appears to be the single common factor in countries where tooth decay has declined. [96]
Fluoride levels in China and other countries tend to be much higher than in the U.S., the researchers noted. Fluoride has been added to public water supplies in the U.S. for decades.
Fluoride therapy is the use of fluoride for medical purposes. [2] Fluoride supplements are recommended to prevent tooth decay in children older than six months in areas where the drinking water is low in fluoride. [3] It is typically used as a liquid, pill, or paste by mouth. [4] Fluoride has also been used to treat a number of bone diseases. [5]