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Ivermectin is an antiparasitic drug. [7] After its discovery in 1975, [8] its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. [9] Approved for human use in 1987, [10] it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
Oral ivermectin is effective in eradicating scabies, often in a single dose. [4] [15] It is the treatment of choice for crusted scabies, and is sometimes prescribed in combination with a topical agent. [15] [19] It has not been tested on infants, and is not recommended for children under six years of age. [19]
Oral ivermectin (while not FDA approved specifically for scabies treatment) deserves consideration as it has shown to be a more practical and effective treatment. Dosage is based on body weight ...
Permethrin, sulfur, lindane, dicophane, benzyl benzoate, ivermectin and crotamiton are well known ectoparasiticides. [2] Additionally, ectoparasiticides have been used to safely contaminate rhinoceros horns with hopes of it deterring the demand for these horns on the black market.
For treatment of scabies: Adults and children older than 2 months are instructed to apply the cream to the entire body from head to the soles of the feet. Wash off the cream after 8–14 hours. In general, one treatment is curative. [17] A single application of permethrin is more effective than a single oral dose of ivermectin for scabies.
The scabies mite Sarcoptes scabiei var. hominis goes through four stages in its lifecycle: egg, larva, nymph, and adult. Upon infesting a human host, the adult female burrows into the stratum corneum (outermost layer of skin), where she deposits two or three eggs per day. These oval eggs are 0.1–0.15 mm (0.0039–0.0059 in) long and hatch as ...
However, these drugs have little effect on the autoinfective larvae. Hence, repeat treatments with ivermectin or albendazole must be administered to kill newly matured parasites that have developed from the autoinfective larvae. This means a full treatment dose every two weeks until all larvae capable of maturing into adults have been extirpated.
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