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  2. Janus kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Janus_kinase_inhibitor

    A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.

  3. Oclacitinib - Wikipedia

    en.wikipedia.org/wiki/Oclacitinib

    Oclacitinib lacks the side effects that most JAK inhibitors have in humans; instead, side effects are infrequent, mild, and mostly self-limiting. [13] [14] [16] The most common side effects are gastrointestinal problems (vomiting, diarrhea, and appetite loss) and lethargy. The GI problems can sometimes be alleviated by giving oclacitinib with food.

  4. Ruxolitinib - Wikipedia

    en.wikipedia.org/wiki/Ruxolitinib

    Ruxolitinib (sold under the brand names Jakafi and Jakavi among others, and as Opzelura in cream form) is a medication used for the treatment of intermediate or high-risk myelofibrosis, [6] a type of myeloproliferative neoplasm that affects the bone marrow; [11] [12] polycythemia vera, when there has been an inadequate response to or intolerance of hydroxyurea; [6] [13] and steroid-refractory ...

  5. Upadacitinib - Wikipedia

    en.wikipedia.org/wiki/Upadacitinib

    This has led to dose-limiting side effects in this otherwise promising class of drugs. [29] [30] Upadacitinib is a second generation Janus kinase inhibitor that is selective for the JAK1 subtype of this enzyme over the JAK2 (74-fold), JAK3 (58-fold) and tyrosine kinase 2 subtypes. [31]

  6. Tofacitinib - Wikipedia

    en.wikipedia.org/wiki/Tofacitinib

    [8] [9] [10] It is a janus kinase (JAK) inhibitor, [8] [9] discovered and developed by the National Institutes of Health and Pfizer. Common side effects include diarrhea, headache, and high blood pressure. [10] Serious side effects may include infections, cancer, and pulmonary embolism.

  7. Common Causes of Arthritis for Women (& How to Treat It) - AOL

    www.aol.com/common-causes-arthritis-women-treat...

    Small molecule DMARDs, called JAK inhibitors, like tofacitinib (Xeljanz®) and upadacitinib (Rinvoq®) Colchicine to treat or prevent gout attacks Antibiotics for bacterial infections

  8. Baricitinib - Wikipedia

    en.wikipedia.org/wiki/Baricitinib

    Baricitinib is a Janus kinase (JAK) inhibitor that reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC 50) of 5.9 nM and Janus kinase 2 with an IC 50 of 5.7 nM. Tyrosine kinase 2 , which belongs to the same enzyme family, is affected less (IC 50 = 53 nM), and Janus kinase 3 far less (IC 50 > 400 nM).

  9. Can JAK Inhibitors Challenge Biologics?

    www.aol.com/news/2013-02-20-can-jak-inhibitors...

    If JAK inhibitors can show similarly impressive results, gain approval, and make a splash, then these blockbuster biologics could have some real competition. While the future is promising that "if ...

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