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Pepto-Bismol is an over-the-counter drug currently produced by the Procter & Gamble company in the United States, Canada and the United Kingdom. Pepto-Bismol is made in chewable tablets [ 24 ] and swallowable caplets, [ 25 ] but it is best known for its original formula, which is a thick liquid.
Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine.
Bismuth subsalicylate (Pepto-Bismol), loperamide (Imodium), and atropine/diphenoxylate (Lomotil) are antidiarrheal agents that can be used to treat diarrhea. However, not all of them are safe to use during pregnancy. One of the components of bismuth subsalicylate is salicylate, which is a component that crosses the placenta.
It is an active ingredient in stomach-relief aids such as Pepto-Bismol and some formulations of Kaopectate. Other derivatives include methyl salicylate , used as a liniment to soothe joint and muscle pain, and choline salicylate , which is used topically to relieve the pain of mouth ulcers .
In the mid-1990s, Norwich constructed an Intermediate Potency solid dose form facility, from which the osteoporosis drug Actonel was launched. In 2001, the North Norwich plant was purchased from Procter & Gamble by Outsourcing Services Group, who revived the original Norwich Pharmaceuticals name by placing it on the sign in front of the plant ...
It is a first-line treatment for amebiasis or giardiasis during pregnancy. [3] Otherwise, it is generally a second line treatment option. [3] It is taken by mouth, applied to the skin, or by injection into a muscle. [3] Common side effects when taken by mouth include loss of appetite, vomiting, abdominal pain, and diarrhea. [3]
Dose – For children, 5 to 20 drops, adults, 1 to 2 tea-spoons. The Medical Companion, Or Family Physician , a book from 1827, gave the following recipe: Paregoric Elixir – Take of purified opium, flowers of Benzoin, camphor, and essential oil of annis-seed, each, two drachms; brandy, two pints.
Following a 100 mg dose of eluxadoline, the C max was about 2 to 4 ng/ml and AUC was 12 to 22 ng.h/ml. Eluxadoline has linear pharmacokinetics with no accumulation upon repeated twice daily dosing. Taking eluxadoline with high fat meal decreased the C max by 50% and AUC by 60%.