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Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers. [1] They are used in the treatment of hypertension.
Benzothiazepine calcium channel blockers belong to the benzothiazepine class of compounds and are an intermediate class between phenylalkylamine and dihydropyridines in their selectivity for vascular calcium channels. By having both cardiac depressant and vasodilator actions, benzothiazepines are able to reduce arterial pressure without ...
A recurring feature of 1,4-dihydropyridines is the presence of substituents at the 2- and 6-positions. Dihydropyridines are enamines, which otherwise tend to tautomerize or hydrolyze. [citation needed] The dominant reaction of dihydropyridines is their ease of oxidation.
One of the most recognized characteristics of the L-type calcium channel is its unique sensitivity to 1,4-dihydropyridines (DHPs). [3] Unlike other voltage gated calcium channels, L-type calcium channels are resistant to ⍵-CT X (GVIA) and ⍵-AG A (IVA) inhibitory drugs. [3] A well observed form of modulation is due to alternative splicing. A ...
Pages in category "Dihydropyridines" The following 32 pages are in this category, out of 32 total. This list may not reflect recent changes. ...
The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammonia.
779 12292 Ensembl ENSG00000081248 ENSMUSG00000026407 UniProt Q13698 Q02789 RefSeq (mRNA) NM_000069 NM_001081023 NM_014193 RefSeq (protein) NP_000060 NP_001074492 NP_055008 NP_001389878 Location (UCSC) Chr 1: 201.04 – 201.11 Mb Chr 1: 135.98 – 136.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ca v 1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S ...
Hantzsch ester refers to an organic compound with the formula HN(MeC=C(CO 2 Et)) 2 CH 2 where Me = methyl (CH 3) and Et = ethyl (C 2 H 5).It is a light yellow solid. The compound is a 1,4-dihydropyridine.
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