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A study that used high- to very-high-dose oral estradiol to treat postmenopausal women with estrogen receptor-positive breast cancer found that mean steady-state estradiol levels in the 6 mg/day group were about 300 pg/mL and in the 30 mg/day group were about 2,400 pg/mL. [37]
Other research has found that the rate of VTE is 1 to 5 in 10,000 woman-years in women who are not pregnant or taking a birth control pill, 3 to 9 in 10,000 woman-years in women who are on a birth control pill, 5 to 20 in 10,000 women-years in pregnant women, and 40 to 65 in 10,000 women-years in postpartum women. [104]
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
Estradiol valerate is usually used in the treatment of advanced prostate cancer in men at a dosage of 30 mg or more every 1 to 2 weeks by intramuscular injection. [13] In transgender women, estradiol valerate given by intramuscular injection is usually used at a dosage of 5 to 20 mg, but up to 30 to 40 mg, once every 2 weeks.
Synthetic conjugated estrogens (Cenestin, Enjuvia) [1] – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg Atypical (dual estrogen and nitrogen mustard alkylating antineoplastic ): Estramustine phosphate sodium (Emcyt) – 140 mg
Estrogen can also reduce vaginal atrophy and increase sexual arousal, frequency and orgasm. [22] The effectiveness of hormone replacement can decline in some women after long-term use. [22] A number of studies have also found that the combined effects of estrogen/androgen replacement therapy can increase libido and arousal over estrogen alone. [22]
Research shows men are more likely than women to avoid—or delay—necessary medical care, even when their symptoms disrupt their lives or become chronic. An online survey conducted by the ...
Estradiol, testosterone, and prolactin levels with 100 mg/month estradiol undecylate in oil by intramuscular injection in 14 to 28 men with prostate cancer. [65] A follow-up of the study with more men and with additional hormones was also subsequently published. [70] Sources were Jacobi & Altwein (1979) and Derra (1981). [65] [70]
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