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  2. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

  3. p53 upregulated modulator of apoptosis - Wikipedia

    en.wikipedia.org/wiki/P53_upregulated_modulator...

    The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. [5] [6] In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. [5] [6] The expression of PUMA is regulated by the tumor suppressor p53.

  4. P53 p63 p73 family - Wikipedia

    en.wikipedia.org/wiki/P53_p63_p73_family

    The p53 p63 p73 family is a family of tumor suppressor genes. [1] [2] This gene family codes the proteins: p53; TP73L (also known as "p63") p73; They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis. [3]

  5. Mdm2 - Wikipedia

    en.wikipedia.org/wiki/Mdm2

    Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. Mdm2 is a p53 responsive gene—that is, its transcription can be activated by p53.

  6. Try these four expert-approved treat-delivery methods to keep ...

    www.aol.com/try-four-expert-approved-treat...

    “It’s not what you feed, it’s the way you feed it,” explains Burton. “Your treat delivery technique can have a powerful impact on the outcome of your training.”

  7. LRDD - Wikipedia

    en.wikipedia.org/wiki/LRDD

    The cleavage of full-length PIDD1 (FL-PIDD1) into PIDD-C or PIDD-CC seems to occur constitutively, meaning it happens regularly, which makes FL-PIDD1 levels remain low even when p53 is activated. However, the observation that PIDD-C accumulates before PIDD-CC in response to DNA damage supports the idea that PIDD-C is the primary form generated ...

  8. Doctors Say This Nighttime Behavior Can Be A Sign Of Dementia

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    Again, showing symptoms of sundowning doesn’t automatically mean that your loved one has dementia—but it is something to get checked out. “As soon as you suspect sundowning changes in your ...

  9. The 15 best subscription gifts of 2024, no shipping required

    www.aol.com/lifestyle/best-subscription-gifts...

    Escape the Crate offers the experience of an escape room, but delivered to the recipient’s home. Every game is complete with a theme, story, clues, and props, and can take several hours to crack ...