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Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. [2] [3] This organoarsenic compound was the first modern antimicrobial agent. [4]
As it was an arsenic based compound, it was also toxic. Salvarsan would later be replaced by antibiotics such as penicillin. The drug in the kit was made by a German manufacturer Farbwerke vorm Meister Lucius & Bruning AG and is stamped with the date “3 February 1912”.
Both Salvarsan and Neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications. [1] This scheme is the basis for most modern pharmaceutical research.
Manufactured by Hoechst AG, Salvarsan became the most widely prescribed drug in the world. It was the most effective drug for treating syphilis until penicillin became available in the 1940s. [ 19 ] Salvarsan required improvement as to side effects and solubility and was replaced in 1911 with Neosalvarsan .
Therefore, Hata's and Ehrlich's work represents a turning point for experimental and therapeutic pharmacology and paved the way for the development of antibiotics decades later. [4] Salvarsan was established as the standard treatment for syphilis until it was replaced by the antibiotic penicillin after World War II, which has fewer adverse side ...
Salvarsan treatment kit for syphilis, Germany, 1909–1912 [1]. The Soviet–German Syphilis Expedition was a joint Soviet and German expedition that took place in 1928. It comprised eight medical researchers from each country and its purpose was to investigate endemic syphilis in the Kul’skoe region of the Buryat-Mongolian Autonomous Republic in Siberia and to determine the efficacy of the ...
Schlenker said she used STRmix to analyze DNA from the inside collar of a long-sleeved shirt found in the defendant's home and concluded the DNA was that of a two-person mixture and that Paul ...
The first effective treatment for syphilis was arsphenamine, discovered by Sahachiro Hata in 1909, during a survey of hundreds of newly synthesized organic arsenical compounds led by Paul Ehrlich. It was manufactured and marketed from 1910 under the trade name Salvarsan by Hoechst AG . [ 113 ]