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These agents work by binding to phosphate in the GI tract, thereby making it unavailable to the body for absorption.Hence, these drugs are usually taken with meals to bind any phosphate that may be present in the ingested food.
Fermagate is a new inorganic phosphate binder developed for the control of blood plasma phosphate, a key therapeutic aim in the prevention of hyperphosphataemia in haemodialysis patients. It is currently under evaluation in clinical trials. Fermagate is an iron magnesium hydroxy carbonate with the general formula, [Mg 4 Fe 2 (OH) 12].CO 3.4H 2 O.
Pages in category "Phosphate binders" The following 10 pages are in this category, out of 10 total. This list may not reflect recent changes. ...
These were first reported in ATP-binding proteins by Walker and co-workers in 1982. [1] Of the two motifs, the A motif is the main "P-loop" responsible for binding phosphate, while the B motif is a much less conserved downstream region. The P-loop is best known for its presence in ATP- and GTP-binding proteins, and is also found in a variety of ...
The term phosphate is also used in organic chemistry for the functional groups that result when one or more of the hydrogens are replaced by bonds to other groups. These acids, together with their salts and esters , include some of the best-known compounds of phosphorus, of high importance in biochemistry , mineralogy , agriculture , pharmacy ...
Sucroferric oxyhydroxide, sold under the brand name Velphoro, is a non-calcium, iron-based phosphate binder used for the control of serum phosphorus levels in adults with chronic kidney disease (CKD) on hemodialysis (HD) or peritoneal dialysis (PD). [6]
Colestilan (INN, trade name BindRen) is a medication that acts as a phosphate binder [1] and bile acid sequestrant. [2] It is an ion-exchange resin, is an orally administered bile acid sequestrant that is being developed by Mitsubishi Tanabe Pharma Corporation for the treatment of hypercholesterolaemia and hyperphosphataemia.
A binder or binding agent is any material or substance that holds or draws other materials together to form a cohesive whole mechanically, chemically, by adhesion or cohesion. More narrowly, binders are liquid or dough-like substances that harden by a chemical or physical process and bind fibres, filler powder and other particles added into it.
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