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The trial, CAPRISA 004, was conducted among 889 women to evaluate the ability of 1% tenofovir gel to prevent male-to-female HIV transmission. The study found a 39% lower HIV infection rate in women using 1% tenofovir gel compared with women using a placebo gel. In addition, tenofovir gel was shown to be safe as tested. [21]
The ideal vaginal microbicide would have the following characteristics: provide protection against infection not require application at the time of intercourse not harm the natural tissue [3] As of 2009, not harming natural tissue was the most troublesome aspect of development.
CAPRISA 004 was a phase IIb, double-blind, randomized, placebo-controlled study comparing 1% tenofovir gel with a placebo gel. 900 young women who were judged to be at risk of contracting HIV volunteered to use a study gel in their vaginas, with half of those receiving the microbicide gel and the other half getting the placebo (according to their randomization results).
Some women develop cysts after trauma to the vaginal walls (like childbirth or surgery). ... Genital herpes is an extremely common sexually transmitted infection — one in six Americans have it ...
Nonoxynol-9 is a common ingredient of most vaginal and anal lubricants due to its spermicidal properties. A 2004 study found that over a six-month period, the typical-use failure rates for five nonoxynol-9 vaginal contraceptives (film, suppository, and gels at three different concentrations) ranged from 10% to 20%.
“The most common cause of vaginal odor is an imbalance in the normal flora in the vagina,” which causes a fishy odor, irritation, and thin to no vaginal discharge, says Dr. Streicher.
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