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Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist) and timolol (a β adrenergic blocker).
Brimonidine is an α 2 agonist medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. [4] [5] In rosacea it improves the redness. [5] It is used as eye drops or applied to the skin. [4] [5] It is also available in the fixed-dose combination medication brimonidine/timolol along with timolol maleate. [6]
Timolol is a beta blocker medication used either by mouth or as eye drops. [ 3 ] [ 5 ] As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma . [ 3 ]
Timolol: Timoptic: Decrease aqueous production: Every 12 hours: 20-30%: bronchospams, bradycardia, depression, impotence Betaxolol: Betoptic: Decrease aqueous production: Every 12 hours: 15-20%: Fewer pulmonary complications due to selective Beta blockage Adrenergic agents: Brimonidine: Alphagan: Decrease aqueous production, increase USO: every ...
A 2013 Cochrane systematic review compared the effect of brimonidine and timolol in slowing the progression of open angle glaucoma in adult participants. [117] The results showed that participants assigned to brimonidine showed less visual field progression than those assigned to timolol, though the results were not significant, given the heavy ...
Brinzolamide works by blocking an enzyme called carbonic anhydrase, which produces bicarbonate needed for the production of the aqueous humour, while brimonidine tartrate blocks another enzyme known as adenylate cyclase, which is also involved in the production of the aqueous humour. [4]
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