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Illustration depicting the layers of the heart wall including the innermost endocardium. The endocardium (pl.: endocardia) is the innermost layer of tissue that lines the chambers of the heart. Its cells are embryologically and biologically similar to the endothelial cells that line blood vessels. The endocardium also provides protection to the ...
Certain diseases such as neuroendocrine tumor of the small intestine (also known by the obsolete term carcinoid), which sometimes release large amounts of 5-hydroxytryptamine, commonly known as 5-HT or serotonin into the blood, may produce a characteristic pattern of mostly right-sided cardiac fibrosis which can be identified with echocardiography.
This notch is far less evident in cells from the endocardium, and the difference between the endocardium and epicardium are most clearly seen in the right ventricle. In those with Brugada syndrome, these differences are increased, creating a brief period within each cardiac cycle when current flows from the endocardium to the epicardium ...
H&E stain with visible Aschoff cells in rheumatic heart disease. In pathology, Aschoff cells (or Aschoff giant cells) are cells associated with rheumatic heart disease. They are found in Aschoff bodies surrounding centres of fibrinoid necrosis. [citation needed] In comparison with Anitschkow cells their cytoplasm is more basophilic and can ...
And, if we take a closer look at one of these zones, we’ll see that basically you’ve got the endocardium, which is the smooth membrane on the inside of the heart, and then the myocardium, all the heart muscle, and then, the epicardium, the outer surface of the heart, which is where the coronary arteries live.
The cardiac manifestations of rheumatic fever are in the form of focal inflammatory involvement of the interstitial tissue in all 3 layers of the heart, a pathological change named pancarditis. The pathognomonic feature of pancarditis in the case of rheumatic heart disease is the presence of Aschoff nodules or Aschoff bodies.
Heart failure is the result of many diseases affecting the heart, but is most commonly associated with ischemic heart disease, valvular heart disease, or high blood pressure. Less common causes include various cardiomyopathies. Heart failure is frequently associated with weakness of the heart muscle in the ventricles (systolic heart failure ...
These categories are called epicardial (above the epicardium, or the outermost tissue of the heart) and microvascular (close to the endocardium, or the innermost tissue of the heart). [ 2 ] Reduced function of the coronary arteries can lead to decreased flow of oxygen and nutrients to the heart.