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Trachoma is an infectious disease caused by bacterium Chlamydia trachomatis. [2] The infection causes a roughening of the inner surface of the eyelids. [2] This roughening can lead to pain in the eyes, breakdown of the outer surface or cornea of the eyes, and eventual blindness. [2]
In mass drug administration (MDA) programmes, the treatment for onchocerciasis is ivermectin (trade name: Mectizan). Ivermectin is administered four times a year and will be continually administered for 10–14 years due to the lifespan of the adult worm. [25] Intense skin itching is eventually relieved, and the progression towards blindness is ...
Chlamydia trachomatis (/ k l ə ˈ m ɪ d i ə t r ə ˈ k oʊ m ə t ɪ s /) is a Gram-negative, anaerobic bacterium responsible for chlamydia and trachoma. C. trachomatis exists in two forms, an extracellular infectious elementary body (EB) and an intracellular non-infectious reticulate body (RB). [2]
Tetracyclines remain the treatment of choice for infections caused by chlamydia (trachoma, psittacosis, salpingitis, urethritis and L. venereum infection), Rickettsia (typhus, Rocky Mountain spotted fever), brucellosis and spirochetal infections (Lyme disease/borreliosis and syphilis). [2] They are also used in veterinary medicine. [2]
Mass drug administration is considered a possible method for eradication, especially for lymphatic filariasis, onchocerciasis, and trachoma, although drug resistance is a potential problem. [138] According to Fenwick, Pfizer donated 70 million doses of drugs in 2011 to eliminate trachoma through the International Trachoma Initiative. [ 16 ]
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As part of a Master of Philosophy in Public Health, he was the principal researcher in evaluating single dose azithromycin for mass treatment of trachoma. This treatment became standard practice partly as a result of Laming's research. [10]
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