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Mirtazapine is sometimes described as a noradrenergic and specific serotonergic antidepressant (NaSSA), [11] although the actual evidence in support of this label has been regarded as poor. [17] It is a tetracyclic piperazine-azepine. [85] Mirtazapine has antihistamine, α 2-blocker, and antiserotonergic activity.
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron) Noradrenergic and specific serotonergic antidepressants ( NaSSAs ) are a class of psychiatric drugs used primarily as antidepressants . [ 1 ]
Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).It has distinct meanings and causes.
These drugs help you sleep better at night, but they don't eliminate the leg sensations, and they may make you drowsy. These medications are generally only used if no other treatment provides ...
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Onset of symptoms is typically within a day of the extra serotonin. [2] Diagnosis is based on a person's symptoms and history of medication use. [2] Other conditions that can produce similar symptoms such as neuroleptic malignant syndrome, malignant hyperthermia, anticholinergic toxicity, heat stroke, and meningitis should be ruled out. [2]
Feeling sleepy and lacking enthusiasm during the day could increase the risk of developing a cognitive disorder leading to dementia, a new study found. Sleep expert Dr. Wendy Troxel discusses.
[8] [1] Unlike low-dose mirtazapine, the half life (10 hours) is short enough that next-day sedation may be manageable, however, for people with CYP2D6 polymorphisms, which constitute a sizable fraction of the population, the half-life is expected to be quite a bit longer. Merck researchers claimed that the incidence of next-day sedation was ...
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