Search results
Results from the WOW.Com Content Network
The purpose of these structures is a balancing of stability of the hairpin loop vs binding strength with a complementary strand. Too strong an initial binding to a bad location and the strands will not unwind quickly enough; too weak an initial binding and the strands will never fully form the desired complex.
The earliest work in RNA structural biology coincided, more or less, with the work being done on DNA in the early 1950s. In their seminal 1953 paper, Watson and Crick suggested that van der Waals crowding by the 2`OH group of ribose would preclude RNA from adopting a double helical structure identical to the model they proposed - what we now ...
Antiparallel and parallel beta sheet. Many proteins may adopt a beta sheet as part of their secondary structure. In beta sheets, sections of a single polypeptide may run side-by-side and antiparallel to each other, to allow for hydrogen bonding between their backbone chains. Beta sheets can also be either a parallel or anti-parallel secondary ...
The Dictionary of Protein Secondary Structure, in short DSSP, is commonly used to describe the protein secondary structure with single letter codes. The secondary structure is assigned based on hydrogen bonding patterns as those initially proposed by Pauling et al. in 1951 (before any protein structure had ever been experimentally determined).
The mechanisms of inflation within these pocket universes could function in a variety of manners, such as slow-roll inflation, undergoing cycles of cosmological evolution, or resembling of the Galilean genesis or other 'emergent' universe scenarios. Lehners goes on to discuss which one of these types of universes we live in, and how that is ...
3' untranslated region (3'-UTR). Also three-prime untranslated region, 3' non-translated region (3'-NTR), and trailer sequence.. 3'-end. Also three-prime end.. One of two ends of a single linear strand of DNA or RNA, specifically the end at which the chain of nucleotides terminates at the third carbon atom in the furanose ring of deoxyribose or ribose (i.e. the terminus at which the 3' carbon ...
What is more commonly observed (see figure to the right) is either a staggered stacking (parallel displaced) or pi-teeing (perpendicular T-shaped) interaction both of which are electrostatic attractive [2] [3] For example, the most commonly observed interactions between aromatic rings of amino acid residues in proteins is a staggered stacked ...
However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity. Longer sequences, which contain two contiguous runs of three or more guanine bases, where the guanine regions are separated by one or more bases, only require two such sequences to provide enough guanine bases to form a quadruplex.