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Current Topics in Medicinal Chemistry is a biweekly peer-reviewed medical journal published by Bentham Science Publishers. It includes review articles on all aspects of medicinal chemistry, including drug design. The current editor-in-chief is Jia Zhou (University of Texas, Medical Branch).
Over a hundred of the 224 drugs mentioned in the Huangdi Neijing – an early Chinese medical text – are herbs. [11] Herbs also commonly featured in the medicine of ancient India, where the principal treatment for diseases was diet. [12] A sample of raw opium. Opioids are among the world's oldest known drugs.
Modern drug discovery involves the identification of screening hits, [3] medicinal chemistry, [4] and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.
Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Atta-ur-Rahman, FRS (Kings College University of Cambridge Cambridge, UK). The journal covers developments in medicinal chemistry and rational drug design and publishes original research reports and review papers. [2]
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use.
Drug Manufacturer Indication Abrocitinib: Pfizer: atopic dermatitis: Tebentafusp: Immunocore: HLA-A*02:01–positive uveal melanoma: Sutimlimab: Bioverativ: cold agglutinin disease: Lutetium (177Lu) vipivotide tetraxetan: Novartis: prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant. prostate cancer (mCRPC ...
Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. [1] The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein , which in turn results in a ...
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.