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Increase in systemic exposure is proportional over the dose range of 50–400 mg. No time-dependent change in kinetics was observed through 12 weeks of dosing. Apparent steady state for armodafinil was reached within 7 days of dosing. At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose.
Modafinil is a drug that helps keep people awake and alert (wakefulness-promoting agent or "eugeroic"). [ 1 ] [ 2 ] Most of the listed modafinil analogues are drugs that specifically target dopamine reuptake (reabsorption of a neurotransmitter by a neurotransmitter transporter ) with stronger effects ( selective DRIs with improved potency ...
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
The Food and Drug Administration has issued warnings about multiple honey packet brands, citing hidden drug ingredients in the product. The big problem, doctors say, is that when you ingest a ...
Hints and the solution for today's Wordle on Thursday, November 21. ... Colorado's Travis Hunter wins 2024 Heisman Trophy over Boise State's Ashton Jeanty. Sports. NBC Universal.
Luigi Mangione, who authorities accuse of murdering UnitedHealthcare CEO Brian Thompson, allegedly wrote in a notebook that he considered bombing Manhattan to carry out the killing but did not ...
Of the more than twenty compounds preclinically tested in Cephalon's three-part drug discovery series, the compound fluorenol was selected as a lead. [26] Fluorenol was found to induce wakefulness to a greater degree than modafinil, despite possessing a lower affinity for the dopamine transporter (DAT). [ 26 ]
There's still about a month to go, but US stocks are headed for their best performance in years. The S&P 500 is up about 27% so far this year. That's slightly more than the S&P 500's gain of about ...
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