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Catharanthus roseus is an evergreen subshrub or herbaceous plant growing 1 m (39 in) tall. The leaves are oval to oblong, 2.5–9 cm (1.0–3.5 in) long and 1–3.5 cm (0.4–1.4 in) wide, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm (0.4–0.7 in) long; they are arranged in opposite pairs.
Catharanthus is a genus of flowering plants in the family Apocynaceae.Like the genus Vinca, they are known commonly as periwinkles. [3] There are eight known species. Seven are endemic to Madagascar, [4] though one, C. roseus, is widely naturalized around the world.
The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, [1] including catharanthine and vindoline [2] and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine [3] and vincristine, [4] all of which can be obtained from the plant.
Vinca difformis in habitat, Cáceres, Spain. Vinca plants are subshrubs or herbaceous, and have slender trailing stems 1–2 m (3 + 1 ⁄ 2 – 6 + 1 ⁄ 2 ft) long but not growing more than 20–70 cm (8– 27 + 1 ⁄ 2 in) above ground; the stems frequently take root where they touch the ground, enabling the plant to spread widely.
Catharanthus roseus yields alkaloids used in the treatment of cancer. [22] [23] Tabernanthe iboga, Voacanga africana, and Tabernaemontana undulata contain the alkaloid ibogaine, which is a psychedelic drug which may help with drug addiction, but which has significant adverse effects, [24] [25] with ibogaine being both cardiotoxic and neurotoxic ...
Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and also in the genus Voacanga [1] (both taxa belonging to the alkaloid-rich family Apocynaceae). Tabersonine is hydroxylated at the 16 position by the enzyme tabersonine 16-hydroxylase (T16H) to form 16-hydroxytabersonine. [2]
The natural extraction of vincristine from Catharanthus roseus is produced at a percent yield of less than 0.0003%. For this reason, alternate methods to produce synthetic vincristine are being used. [22] Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. [23]
Catharanthus or Madagascar periwinkles Catharanthus roseus or rosy periwinkle; Vinca or European periwinkles Vinca major or greater periwinkle; Vinca minor or lesser periwinkle; Vinca herbacea or herbaceous periwinkle
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