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Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. [1] However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin ...
Common types of myopathy due to statins include myalgia, myositis, and rhabdomyolysis. Statins induce myopathy by inhibiting protein synthesis within the muscle. [6] Statin therapy tends to not show any histopathological differences, and thus a biopsy does not reveal too much about the damage. Often, the damage is found within the mitochondria.
Statins (prescription drugs to lower cholesterol) are considered a small risk. [9] Some people have inherited muscle conditions that increase the risk of rhabdomyolysis. [3] The diagnosis is supported by a urine test strip which is positive for "blood" but the urine contains no red blood cells when examined with a microscope. [3]
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Statins or other medications to treat high cholesterol levels Medications to treat blood clots If your doctor thinks that you’re at a high risk of developing complications, they may recommend ...
Medicines - A variety of different medicines can cause myositis. One of the most common types of drugs that can cause myositis are statins, which are used to lower cholesterol levels. One of the most common side effects of statin therapy is muscle pain [5] which, more rarely, can lead to myositis. [5]
Statin-induced hepatotoxicity can cause autoimmune hepatitis and an elevation in serum levels of hepatic enzymes such as alanine aminotransferase, impairing liver function. [20] Myotoxicity is commonly presented with statin-associated muscle symptoms (SAMS), which include myalgia and myositis. [21]
In other words, as many as 4 million people in the U.S. who currently take statins for primary prevention — meaning they have not had a cardiovascular event such as a stroke or heart attack ...