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  2. DNA unwinding element - Wikipedia

    en.wikipedia.org/wiki/DNA_unwinding_element

    A DNA unwinding element (DUE or DNAUE) is the initiation site for the opening of the double helix structure of the DNA at the origin of replication for DNA synthesis. [1] It is A-T rich and denatures easily due to its low helical stability, [ 2 ] which allows the single-strand region to be recognized by origin recognition complex .

  3. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    As DNA synthesis continues, the original DNA strands continue to unwind on each side of the bubble, forming a replication fork with two prongs. In bacteria, which have a single origin of replication on their circular chromosome, this process creates a "theta structure" (resembling the Greek letter theta: θ). In contrast, eukaryotes have longer ...

  4. Replication timing - Wikipedia

    en.wikipedia.org/wiki/Replication_timing

    The process of duplicating DNA is called DNA replication, and it takes place by first unwinding the duplex DNA molecule, starting at many locations called DNA replication origins, followed by an unzipping process that unwinds the DNA as it is being copied. However, replication does not start at all the different origins at once.

  5. DNA synthesis - Wikipedia

    en.wikipedia.org/wiki/DNA_synthesis

    DNA synthesis is the natural or artificial creation of deoxyribonucleic acid (DNA) molecules. DNA is a macromolecule made up of nucleotide units, which are linked by covalent bonds and hydrogen bonds, in a repeating structure.

  6. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    DNA replication on the lagging strand is discontinuous. In lagging strand synthesis, the movement of DNA polymerase in the opposite direction of the replication fork requires the use of multiple RNA primers. DNA polymerase will synthesize short fragments of DNA called Okazaki fragments which are added to the 3' end of the primer. These ...

  7. Molecular Structure of Nucleic Acids: A Structure for ...

    en.wikipedia.org/wiki/Molecular_Structure_of...

    Watson and Crick used many aluminium templates like this one, which is the single base Adenine (A), to build a physical model of DNA in 1953. When Watson and Crick produced their double helix model of DNA, it was known that most of the specialized features of the many different life forms on Earth are made possible by proteins .

  8. DNA - Wikipedia

    en.wikipedia.org/wiki/DNA

    DNA profiling was developed in 1984 by British geneticist Sir Alec Jeffreys, [166] and first used in forensic science to convict Colin Pitchfork in the 1988 Enderby murders case. [167] The development of forensic science and the ability to now obtain genetic matching on minute samples of blood, skin, saliva, or hair has led to re-examining many ...

  9. Molecular models of DNA - Wikipedia

    en.wikipedia.org/wiki/Molecular_models_of_DNA

    For simplicity most DNA molecular models omit both water and ions dynamically bound to B-DNA, and are thus less useful for understanding the dynamic behaviors of B-DNA in vivo. The physical and mathematical analysis of X-ray [16] [17] and spectroscopic data for paracrystalline B-DNA is thus far more complex than that of crystalline, A-DNA X-ray ...

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