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[25] [26] Lusduna was approved for medical use in the European Union in January 2017. [27] In March 2018, insulin glargine (Semglee) was approved for medical use in the European Union. [28] In July 2021, insulin glargine-yfgn (Semglee) was approved for medical use in the United States as the first interchangeable biosimilar of Lantus. [12]
It is given as an injection under the skin in the abdominal wall (at the front of the waist), upper arm or thigh. [6] The most frequently reported side effect is hypoglycemia (low blood glucose levels). [6] It was approved for medical use in the European Union in January 2013, [6] and in Australia in November 2017. [2]
Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. [5] It is delivered subcutaneously either by injection or from an insulin pump.
The insulin aspart protamine portion is a crystalline form of insulin aspart, which delays the action of the insulin, giving it a prolonged absorption profile after injection. [14] The combination of the fast-acting form and the long-acting form allows the patient to receive fewer injections over the course of the day.
Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion. A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. The instruments are usually a hypodermic needle and a syringe.
Other side effects may include pain or skin changes at the sites of injection, low blood potassium, and allergic reactions. [3] Use during pregnancy is relatively safe for the fetus. [3] NPH insulin is made by mixing regular insulin and protamine in exact proportions with zinc and phenol such that a neutral-pH is maintained and crystals form. [1]
The number of patients who discontinued taking tirzepatide also increased as the dosage increased, with patients taking 15 mg having a 25% discontinuation rate vs 5.1% for 5 mg patients and 11.1% for dulaglutide. [28] [clarification needed] To a slightly lesser extent, patients also reported reduced appetite. [27]
The primary use of sterile water for injection is as an ingredient for dilution of other medications (aseptic preparation of parenteral solutions). [6] If it is given by injection into a vein without making it approximately isotonic, breakdown of red blood cells may occur. [3] This can then result in kidney problems. [3]