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Schematic diagram of NF-κB protein structure. [1] There are two structural classes of NF-κB proteins: class I (top) and class II (bottom). Both classes of proteins contain a N-terminal DNA-binding domain (DBD), which also serves as a dimerization interface to other NF-κB transcription factors and, in addition, binds to the inhibitory IκBα ...
Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene. [ 5 ] This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein.
Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene. [5] Function. NF-κB has been detected in numerous cell types that ...
IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB.
The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation ...
67050 Ensembl ENSG00000101882 ENSMUSG00000016409 UniProt Q8N5F7 Q9D0F4 RefSeq (mRNA) NM_024528 NM_025937 RefSeq (protein) NP_078804 NP_080213 Location (UCSC) Chr X: 119.92 – 119.94 Mb Chr X: 36.39 – 36.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NF-kappa-B-activating protein is a protein that in humans is encoded by the NKAP gene. References ^ a b c GRCh38: Ensembl release ...
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. [5] IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. [6]
NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. [5] The human gene for IKBKG is located on the chromosome band Xq28. [6]