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Adapalene Gel, sold in trade name Differin in China. Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6]
Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. [8] [9] [10] For acne, it is applied to the skin as a cream, gel or ointment. [10]
Toxic effects of retinoids occur with both acute or prolonged intake, depending on which retinoid is considered. The specific toxicity is related to the mechanism of action as well as exposure. A medical sign of chronic or acute poisoning with retinol is hypervitaminosis A , which includes the presence of painful tender swellings on the long bones.
Adapalene: The only prescription-strength retinoid available over the counter, adapalene is a synthetic retinoid that does not need any conversion in the skin to become active. Hearst Owned Can I ...
Adapalene Gel Acne Treatment. I used this affordable gel and swore by its efficacy through my teen acne years. "This gel is much gentler than other products but it contains a powerful retinoid to ...
The first prescription-strength retinoid acne treatment available over the counter, this La Roche-Posay gel helps clear and prevent blackheads, whiteheads, clogged pores and blemishes.
Tretinoin (category C) and adapalene (category C) are very poorly absorbed, but certain studies have suggested teratogenic effects in the first trimester. [176] The data examining the association between maternal topical retinoid exposure in the first trimester of pregnancy and adverse pregnancy outcomes is limited. [ 177 ]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
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