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Normally, the amount of biotin in the body is regulated by dietary intake, biotin transporters (monocarboxylate transporter 1 and sodium-dependent multivitamin transporter), peptidyl hydrolase biotinidase (BTD), and the protein ligase holocarboxylase synthetase. When any of these regulatory factors are inhibited, biotin deficiency could occur. [23]
Biotinidase deficiency is an autosomal recessive metabolic disorder in which biotin is not released from proteins in the diet during digestion or from normal protein turnover in the cell. This situation results in biotin deficiency. Biotin is an important water-soluble nutrient that aids in the metabolism of fats, carbohydrates, and proteins.
Some vitamin deficiencies, such as a biotin deficiency and iron deficiency, can lead to hair loss or unhealthy hair. (Related: 12 Best Vitamins for Hair Growth ) Chris6 / iStock
Again, for those who don't have a diagnosed biotin deficiency, there's not enough evidence to support that biotin is the most effective method for hair growth. In general, biotin can "improve the ...
In the U.S., as many as 43 percent of older adults have vitamin B12 deficiency. Symptoms of insufficient vitamin B12 can include fatigue, palpitations, pale skin, numbness, weight loss ...
The signs and symptoms of holocarboxylase synthetase deficiency typically appear within the first few months of life, but the age of onset varies. Affected infants often have immunodeficiency diseases, difficulty feeding, breathing problems, a skin rash, hair loss , and a lack of energy . Immediate treatment and lifelong management (using ...
Discover what this essential B vitamin can do for your body and whether you need more in your diet.
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Biotinidase Identifiers Symbol BTD NCBI gene 686 HGNC 1122 OMIM 609019 RefSeq NM_000060 UniProt P43251 Other data EC number 3.5.1.12 Locus Chr. 3 p25 Search for Structures Swiss-model Domains InterPro Biotinidase (EC 3.5.1.12, amidohydrolase ...
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