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As per Falkow's original descriptions, the three postulates are: [1] "The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species. Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or ...
In 1988, microbiologist Stanley Falkow developed a set of three Molecular Koch's postulates for identifying the microbial genes encoding virulence factors. First, the phenotype of a disease symptom must be associated with a specific genotype only found in pathogenic strains. Second, that symptom should not be present when the associated gene is ...
Falkow is known as the father of the field of molecular microbial pathogenesis. [1] He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. [2] Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. [1]
Microbial pathogenesis is a field of microbiology that started at least as early as 1988, with the identification of the triune Falkow's criteria, aka molecular Koch's postulates.
The biological basis of personality is a collection of brain systems and mechanisms that underlie human personality. Human neurobiology, especially as it relates to complex traits and behaviors, is not well understood, but research into the neuroanatomical and functional underpinnings of personality are an active field of research.
Personality disorder, unspecified (includes "character neurosis" and "pathological personality"). Mixed and other personality disorders (defined as conditions that are often troublesome but do not demonstrate the specific pattern of symptoms in the named disorders).
Personality pathology refers to enduring patterns of cognition, emotion, and behavior that negatively affect a person's adaptation. In psychiatry and clinical psychology , it is characterized by adaptive inflexibility, vicious cycles of maladaptive behavior, and emotional instability under stress.
Dimensional models are intended to reflect what constitutes personality disorder symptomology according to a spectrum, rather than in a dichotomous way.As a result of this they have been used in three key ways; firstly to try to generate more accurate clinical diagnoses, secondly to develop more effective treatments and thirdly to determine the underlying etiology of disorders.