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In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.
Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. [18] It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal), or as an implant.
The gauge of the needle used can range from 25 gauge to 27 gauge, while the length can vary between 1 ⁄ 2-inch to 5 ⁄ 8-inch for injections using a syringe and needle. [ 3 ] : 722 For subcutaneous injections delivered using devices such as injector pens , the needle used may be as thin as 34 gauge (commonly 30–32 gauge), and as short as 3 ...
However, in common English the term has mostly been used to describe the four most well-known routes of injection. A peripheral IV placed on the hand. A medical professional performs an intradermal (ID) injection. The term injection encompasses intravenous (IV), intramuscular (IM), subcutaneous (SC) and intradermal (ID) administration. [35]
A dose of methadone often minimizes the effects of withdrawal for approximately 24 hours and the lowest optimal dose is 60 mg. [8] Methadone functions via competitive antagonism; while the prescribed agonist is in the opioid user's body, the use of illicit opioids (illicit heroin or fentanyl) will not produce the effects of illicit opioids. [8]
The punctures should remain in an area approximately 5 mm in diameter. The needle is then disposed of. When done correctly a trace of blood appears at the vaccination site within 10 to 20 seconds after the procedure. [3] [4] The bifurcated needle was created as a more efficient and cost effective alternative to the jet injector previously in use.
Injector pens may also remove stigma or fear around the use of injection medication in public environments, such as insulin before a meal at a restaurant. [2] Combination injector pens which include multiple medications used to treat a disease are designed to reduce the number of injections a person must use to administer their medications. [3]
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
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