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Atomoxetine, formerly sold under the brand name Strattera [12], is a selective norepinephrine reuptake inhibitor (sNRI) medication used to treat attention deficit hyperactivity disorder (ADHD) [13] and, to a lesser extent, cognitive disengagement syndrome (CDS). [14] [15] [16] It may be used alone or along with stimulant medication.
One hypothesis is that after the antidepressant is discontinued, there is a temporary (but in some cases long-lasting) deficiency in the brain of one or more essential neurotransmitters that regulate mood, such as serotonin, dopamine, norepinephrine, and gamma-aminobutyric acid, and since neurotransmitters are an interrelated system ...
Atomoxetine is very water soluble so it absorbed rapidly and completely after oral administration. [18] Atomoxetine reaches C max 1 to 2 hours after administration. The bioavailability of atomoxetine after oral administration is 63-94%, it is dependent on individual differences in the first-pass metabolism. [18]
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Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [2] The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal insomnia [sFI]).
Studies on rodents show that the response to neuronal injury due to acute sleep deprivation is adaptative before three hours of sleep loss per night and becomes maladaptative, and apoptosis occurs after. [35] Studies in mice show neuronal death (in the hippocampus, locus coeruleus, and medial PFC) occurs after two days of REM sleep deprivation.
Cognitive disengagement syndrome (CDS) is a syndrome characterized by developmentally inappropriate, impairing, and persistent levels of decoupled attentional processing from the ongoing external context and resultant hypoactivity.
The new regulation addresses an ambiguity in California retirement law, which says retirees may return to work for a “limited duration” in emergencies and when employers need retirees ...