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Mifepristone is used in more than half of all abortions in the US. The drug was first approved for use by the US Food and Drug Administration in most cases up to 10 weeks of pregnancy in 2000.
The mifepristone-misoprostol combination is, by far, the most recommended drug regimen for medical abortions, but other drug combinations are available. Misoprostol alone, without mifepristone, may be used in some circumstances for medical abortion, and has even been demonstrated to be successful in the second trimester. [37]
Mifepristone is a steroidal antiprogestogen (IC 50 = 0.025 nM for the PR), as well as an antiglucocorticoid (IC 50 = 2.2 nM for the GR) and antiandrogen (IC 50 = 10 nM for the AR) to a much lesser extent. [48] It antagonizes cortisol action competitively at the receptor level. [49]
Mifepristone is currently in the middle of a political tug-of-war, with some conservative states seeking to restrict or eliminate access to the abortion pill, while other states are trying to ...
After the 2024 election, women’s reproductive rights are front and center of the news cycle, once again.. According to reports, there has already been a surge in demand for mifepristone, a.k.a ...
Plan C conducts research and publicly shares information about how people are accessing mifepristone and misoprostol abortion pills in the US. Their stated goal is to transform access to abortion in the United States by normalizing the self-directed option of abortion pills by mail and placing the ability to end an early pregnancy directly in the hands of anyone who seeks it.
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Soviet poster circa 1925. Title translation: "Abortions induced by either self-taught midwives or obstetricians not only maim the woman, they also often lead to death". A self-induced abortion (also called a self-managed abortion, or sometimes a self-induced miscarriage) is an abortion performed by the pregnant woman herself, or with the help of other, non-medical assistance.
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