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There is debate regarding whether obesity or insulin resistance is the cause of the metabolic syndrome or if they are consequences of a more far-reaching metabolic derangement. Markers of systemic inflammation , including C-reactive protein , are often increased, as are fibrinogen , interleukin 6 , tumor necrosis factor-alpha (TNF-α), and others.
Obesity is a disease characterized by having excessive body fat, increasing a person’s risk for many serious health problems, such as heart disease, diabetes, and even some cancers.
The disease puts strain on the heart, which may lead to heart failure and leg swelling. Obesity hypoventilation syndrome is defined as the combination of obesity and an increased blood carbon dioxide level during the day that is not attributable to another cause of excessively slow or shallow breathing. [2]
In 2006, the Canadian Obesity Network, now known as Obesity Canada published the "Canadian Clinical Practice Guidelines (CPG) on the Management and Prevention of Obesity in Adults and Children". This is a comprehensive evidence-based guideline to address the management and prevention of overweight and obesity in adults and children. [96]
Being overweight or having obesity may increase the risk of several diseases, such as diabetes, heart disease, and some cancers, and may lead to short- and long-term health problems during pregnancy. [2] Rates of obesity worldwide tripled from 1975 to 2016 to involve some 1.8 billion people and 39% of the world adult population. [3]
Overweight is defined as a BMI of 25 or more, thus it includes pre-obesity defined as a BMI between 25 and 29.9 and obesity as defined by a BMI of 30 or more. [4] [5] Pre-obese and overweight however are often used interchangeably, thus giving overweight a common definition of a BMI of between 25 and 29.9. There are, however, several other ...
Coronary artery disease develops when the arteries that supply your heart become clogged with a fatty substance called plaque. The build-up of plaque is also called atherosclerosis.
“The notable thing for liver cancer is overweight and obesity is a key risk factor, and that has been steadily increasing in the UK - around two-thirds of UK adults are overweight and obese ...