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The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, [1] including catharanthine and vindoline [2] and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine [3] and vincristine, [4] all of which can be obtained from the plant.
The vinca alkaloids include at least 86 alkaloids extracted from plants in the genus Vinca. [ 16 ] [ 17 ] [ 18 ] The chemotherapy agent vincristine is extracted from a closely related species, Catharanthus roseus , [ 19 ] [ 20 ] [ 21 ] and is used to treat some leukemias , [ 22 ] lymphomas , [ 23 ] and childhood cancers, [ 24 ] as well as ...
The newer semi-synthetic chemotherapeutic agent vinorelbine, used in the treatment of non-small-cell lung cancer, [27] [30] can be prepared either from vindoline and catharanthine [27] [31] or from the vinca alkaloid leurosine, [32] in both cases via anhydrovinblastine. [31] The insulin-stimulating vincoline has been isolated from the plant ...
Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. [23] It can also now be synthesized through a stereocontrolled total synthesis technique which retains the correct stereochemistry at C18' and C2'.
Catharanthus roseus, known formerly as Vinca rosea, is a main source of vinca alkaloids, now sometimes called catharanthus alkaloids. The plant produces about 130 of these compounds, including vinblastine and vincristine , two drugs used to treat cancer.
Opiates are alkaloid compounds naturally found in the Papaver somniferum plant (opium poppy). The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD.
Vinca alkaloids were originally manufactured by extracting them from Catharanthus roseus (Madagascar Periwinkle). [1] Podophyllum spp. Two chemotherapy drugs, etoposide and teniposide, are synthetic chemical compounds similar in chemical structure to the toxin podophyllotoxin which is found in Podophyllum peltatum (May Apple). [1] Taxus brevifolia
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids. [1]