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As of 2014, Biochimica et Biophysica Acta encompasses ten specialised sections with a total of 100 annual issues in ten volumes. Over 16,000 pages were published in 2011. The journal sections are published separately, with one annual volume per section (two for Reviews on Cancer), but form part of the volume numbering for Biochimica et Biophysica Acta.
Acta Biochimica et Biophysica Sinica was a Chinese-language journal entitled "Shengwu Huaxue Yu Shengwu Wuli Xuebao" (see box below), which began publishing sometime in 1958 or 1959, or August 1961, until December 2003 (depending on the source). Tables of contents were in English.
[16] [17] As such, the design and development of PTP1B inhibitors is a growing field of research for the treatment of type 2 diabetes and obesity. [ 42 ] Although PTP1B is generally studied as a regulator of metabolism, some research suggest it may have a role in tumor development, though whether it is oncogenic or tumor suppressive is unclear ...
Proteasome subunit beta type-5 also known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. [5] [6] [7] This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.
TP63 encodes for two main isoforms by alternative promoters (TAp63 and ΔNp63). ΔNp63 is involved in multiple functions during skin development and in adult stem/progenitor cell regulation. [11] In contrast, TAp63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. [12]
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
7158 27223 Ensembl ENSG00000067369 ENSMUSG00000043909 UniProt Q12888 P70399 RefSeq (mRNA) NM_001141979 NM_001141980 NM_005657 NM_001355001 NM_001290830 NM_013735 RefSeq (protein) NP_001135451 NP_001135452 NP_005648 NP_001341930 NP_001277759 NP_038763 Location (UCSC) Chr 15: 43.4 – 43.51 Mb Chr 2: 121.02 – 121.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor suppressor p53 ...
In breast cancer and malignant prostate cancer, eIF3h is overexpressed. [ 17 ] eIF3 has also been shown to bind a specific set of cell proliferation mRNAs and regulate their translation. [ 18 ] eIF3 also functions in the life cycles of a number of important human pathogens, including HIV and HCV .
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