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Doctors describe these cancers as being well differentiated. Lower grade cancers are typically less aggressive and have a better prognosis. The more abnormal the cells look and organize themselves, the higher the cancer’s grade.
The NCCN’s Clinical Practice Guidelines in Oncology indicate that well-differentiated SCCs have better prognosis than poorly differentiated carcinomas, as well as lower rates of recurrence and metastasis (based on retrospective studies) .
Invasive squamous cell carcinoma of the skin is divided into three grades – well differentiated, moderately differentiated, and poorly differentiated. The grade is based on how much the tumour cells look like the squamous cells normally found in the skin and it can only be determined after the tumour is examined under the microscope.
Squamous cell cancer (SCC) is a type of skin cancer. To determine the severity of SCC, doctors use a staging system. There are five stages in total, ranging from 0–4. SCC stages describe the...
Cells that look more normal might be called well-differentiated in the pathology report. And cells that look less normal might be called poorly differentiated or undifferentiated. Based on these and other features of how cells look under the microscope, the pathologist will assign a number to describe the grade.
Well-differentiated keratinizing nests of squamous cells with minimal atypia surrounded by a reactive fibrous stroma. Special stains in SCC Immunoperoxidase staining may be helpful in poorly differentiated and spindle cell-type SCC.
Well-differentiated tumors resemble closely their tissue of origin, whereas poorly-differentiated tumors barely resemble their tissue of origin. Check out the images above. The well-differentiated squamous cell carcinoma cells (top image, right side) Â look a lot like the adjacent benign squamous epithelium.
Well-differentiated, low-grade oral squamous cell carcinoma usually metastasizes to regional lymph nodes after invading connective tissue, muscle or bone. On the other hand, poorly differentiated, high-grade oral cancer was biologically more aggressive and tends to metastasize to regional lymph nodes early in the course of the disease. [7]
Low grade or grade I tumors are well-differentiated. This means that the tumor cells are organized and look more like normal tissue. High grade or grade III tumor cells are poorly differentiated. This means that the tumor cells don't look like normal cells.
In this study, we assess the interrater and intrarater reliability of CSCC differentiation grading among dermatopathologists. We recruited 21 fellowship-trained dermatopathologists with at least 5 years of experience reviewing at least 1000 cases annually.