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In individuals with chronic obstructive pulmonary disease who receive supplemental oxygen, carbon dioxide accumulation may occur through two main mechanisms: [6] Ventilation/perfusion matching: under-ventilated lung usually has a low oxygen content which leads to localized vasoconstriction limiting blood flow to that lung tissue.
Hypoxic ventilatory response (HVR) is the increase in ventilation induced by hypoxia that allows the body to take in and transport lower concentrations of oxygen at higher rates. It is initially elevated in lowlanders who travel to high altitude, but reduces significantly over time as people acclimatize .
Under most conditions, the partial pressure of carbon dioxide (PCO 2), or concentration of carbon dioxide, controls the respiratory rate. The peripheral chemoreceptors that detect changes in the levels of oxygen and carbon dioxide are located in the arterial aortic bodies and the carotid bodies . [ 2 ]
The hypoxia challenge of IHT is normally delivered in an intermittent manner: 3-7 min of hypoxic air breathing alternated with 1-5 min of normoxic or hyperoxic air. The hypoxicator allows automated and pre-programmed delivery of the required hypoxic and hyperoxic or normoxic air and safety monitoring.
Acute respiratory acidosis occurs when an abrupt failure of ventilation occurs. This failure in ventilation may be caused by depression of the central respiratory center by cerebral disease or drugs, inability to ventilate adequately due to neuromuscular disease (e.g., myasthenia gravis, amyotrophic lateral sclerosis, Guillain–Barré syndrome, muscular dystrophy), or airway obstruction ...
A controlled F I O 2 is particularly important for patients whose ventilation is dependent on hypoxic drive, [5] as may be seen in patients with chronic obstructive pulmonary disease. Administration of too much oxygen may lead to a reduction in their respiratory rate and retention of carbon dioxide, and ultimately to reduced consciousness or ...
While the maintenance of ventilation/perfusion ratio during regional obstruction of airflow is beneficial, HPV can be detrimental during global alveolar hypoxia which occurs with exposure to high altitude, where HPV causes a significant increase in total pulmonary vascular resistance, and pulmonary arterial pressure, potentially leading to ...
IPI integrates four major physiological parameters provided by a patient monitor, using this information along with an algorithm to produce the IPI score. The IPI score is not intended to replace current patient respiratory parameters, but to provide an additional integrated score or index of the patient ventilation status to the caregiver.