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Morning sickness, also called nausea and vomiting of pregnancy (NVP), is a symptom of pregnancy that involves nausea or vomiting. [ 1 ] Despite the name, nausea or vomiting can occur at any time during the day. [ 2 ] Typically the symptoms occur between the 4th and 16th week of pregnancy. [ 2 ]
Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. [ 1 ] It can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the throat. [ 2 ] Over 30 definitions of nausea were proposed in a 2011 book on the topic.
Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7][4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Previous studies have suggested sickness and nausea in pregnancy could relate to GDF15 being produced by the placenta, but researchers said the “full mechanistic understanding is lacking”.
It is similar although more severe than the common morning sickness. [15] [16] It is estimated to affect 0.3–3.6% of pregnant women and is the greatest contributor to hospitalizations under 20 weeks of gestation. Most often, nausea and vomiting symptoms during pregnancy resolve in the first trimester, however, some continue to experience ...
Scientists are moving forward with researching cures for morning sickness, including testing drugs that block GDF15 from binding to its receptor in the brain, and exposing women to the hormone ...
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, migraines or surgery. [8] It is also effective for treating gastroenteritis. [9][10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...