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An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
A box of Lorazepam Orion (Lorazepam) tablets. Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. [14] It is used to treat anxiety (including anxiety disorders), trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. [14]
Some "Withdrawal Symptoms" can emerge despite a constant dosage with the body needing extra dosage in order to feel normal. This is sometimes associated with dosage escalation. Lormetazepam has a short to intermediate half-life of approximately 10–12 hours. Shorter acting benzodiazepine compounds are generally associated with a more intense ...
Bioavailability is 91% at the standard subcutaneous dose but 24% at the standard oral dose; the standard oral dose is higher to partially compensate for incomplete bioavailability. [ 5 ] [ 18 ] It binds to plasma proteins at a rate of 99.5%; it has a low volume of distribution (9 L/kg) and is thus not extensively absorbed.
The carpuject is a syringe device for the administration of injectable fluid medication. It was patented by the Sterling Drug Company , which became the Sterling Winthrop , after World War II. It is designed with a luer-lock device to accept a sterile hypodermic needle or to be linked directly to intravenous tubing line.
[8] [120] However, they occur with greater frequency in recreational abusers, individuals with borderline personality disorder, children, and patients on high-dosage regimes. [ 121 ] [ 122 ] In these groups, impulse control problems are perhaps the most important risk factor for disinhibition; learning disabilities and neurological disorders ...
Lorazepam is preferred to other benzodiazepines and zolpidem due to its longer duration of action. [4] An initial therapeutic effect typically occurs within 10–30 minutes of IV administration lorazepam at doses between 2–4 mg. [5] [4] Higher doses may be used in patients who are unresponsive, to minimise the chance of a false negative ...
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...