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In a small phase 2 randomized controlled trial, TOL-463 as an insert or gel achieved clinical cure rates of 50 to 59% against BV and 81 to 92% against VVC in women who had one or both conditions. [ 4 ] [ 2 ] [ 1 ] It was effective and safe in the study, though it was without indication of superiority over other antifungal medications for VVC.
Bacterial vaginosis (BV) is an infection of the vagina caused by excessive growth of bacteria. [ 6 ] [ 12 ] Common symptoms include increased vaginal discharge that often smells like fish. [ 2 ] The discharge is usually white or gray in color. [ 2 ]
For women who have irritation and inflammation caused by low levels of estrogen (postmenopausal), a topical estrogen cream might be prescribed. The following are typical treatments for trichomoniasis, bacterial vaginosis, and yeast infections: Trichomoniasis: Oral treatment with either metronidazole or tinidazole. [8] "Sexual partner(s) should ...
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A high vaginal swab (HVS) is a medical procedure performed in obstetrics and gynaecology to test vaginal discharge for the presence of vaginal thrush, bacterial vaginosis and trichomonas vaginalis. [1] [2] [3] It is carried out in clean conditions, by a healthcare professional who uses a speculum to look at the cervix and vagina.
Normal vaginal flora (left) is predominantly rod-shaped Lactobacilli, whereas in bacterial vaginosis (right) there is an overgrowth of bacteria, which can be of various species. A healthy vaginal microbiome aids in the prevention of bacterial vaginosis, yeast infections and other possible problems by maintaining an acidic pH (< 4.5) that is ...
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