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Bromocriptine, originally marketed as Parlodel and subsequently under many brand names, [1] is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes.
Prolactin inhibitors are mainly used to treat hyperprolactinemia (high prolactin levels). [1] Agonists of the dopamine D 2 receptor such as bromocriptine and cabergoline are able to strongly suppress pituitary prolactin secretion and thereby decrease circulating prolactin levels, and so are most commonly used as prolactin inhibitors. [1]
A prolactinoma is a tumor of the pituitary gland that produces the hormone prolactin.It is the most common type of functioning pituitary tumor. [1] Symptoms of prolactinoma are due to abnormally high levels of prolactin in the blood (hyperprolactinemia), or due to pressure of the tumor on surrounding brain tissue and/or the optic nerves.
Prolactin and its receptor are expressed in the skin, specifically in the hair follicles, where they regulate hair growth and moulting in an autocrine fashion. [ 29 ] [ 30 ] Elevated levels of prolactin can inhibit hair growth, [ 31 ] and knock-out mutations in the prolactin gene cause increased hair length in cattle [ 32 ] and mice. [ 30 ]
Medical therapy is the preferred treatment in prolactinomas. [3] In most cases, medications that are dopamine agonists, such as cabergoline, [52] quinagolide and bromocriptine (often preferred when pregnancy is possible), are the treatment of choice used to decrease prolactin levels and tumor size upon the presence of microadenomas or ...
Then, use a skin soothing treatment like calamine lotion to combat the irritation, per the Cleveland Clinic. OTC anti-itch creams or ointments, along with antihistamines can relieve itchy skin and ...
Mayo Clinic is a nonprofit hospital system with campuses in Rochester, Minnesota; Scottsdale and Phoenix, Arizona; and Jacksonville, Florida. [22] [23] Mayo Clinic employs 76,000 people, including more than 7,300 physicians and clinical residents and over 66,000 allied health staff, as of 2022. [5]
Vermont, a state with a long waiting list for medically based drug treatment, suspended a doctor’s license over incomplete paperwork. As doctors face scrutiny from the DEA, states have imposed even greater regulations severely limiting access to the medications, according to a 2014 report commissioned by the federal agency SAMHSA.