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2. Monoclonal B-cell lymphocytosis - Wikipedia

   en.wikipedia.org/wiki/Monoclonal_B-cell_lymphocy...

   Mantle cell lymphoma: The monoclonal B-cells in this aggressive lymphoma are CD5+ in most cases, CD10−, CD23−, CD43+, CD103−, complete Ig+, and express cyclin D1; these cells have translocations between chromosomes 11 and 14 in >95% of cases and in many cases overexpress the SOX11 transcription factor gene. [2]

3. CD5 (protein) - Wikipedia

   en.wikipedia.org/wiki/CD5_(protein)

   CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies), that do not express CD3.

4. Mantle cell lymphoma - Wikipedia

   en.wikipedia.org/wiki/Mantle_cell_lymphoma

   MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to the t(11:14) translocation , [ 6 ] a chromosomal translocation in the DNA .

5. Immunoglobulin light chain - Wikipedia

   en.wikipedia.org/wiki/Immunoglobulin_light_chain

   If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell ...

6. Chronic lymphocytic leukemia - Wikipedia

   en.wikipedia.org/wiki/Chronic_lymphocytic_leukemia

   In CLL, the lymphocytes are all genetically identical since they are derived from the same B cell lineage, expressing common B-cell markers CD19 and CD20, with abnormal expression of surface markers CD5 and CD23. [37] These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a ...

7. B-cell lymphoma - Wikipedia

   en.wikipedia.org/wiki/B-cell_lymphoma

   The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes . They develop more frequently in older adults and in immunocompromised individuals.

8. Splenic marginal zone lymphoma - Wikipedia

   en.wikipedia.org/wiki/Splenic_marginal_zone_lymphoma

   Splenic marginal zone lymphoma (SMZL) is a type of marginal zone lymphoma, a cancer made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed lymphoblasts , and they invade the mantle zone of splenic follicles and erode the marginal zone ...

9. Precursor B-cell lymphoblastic leukemia - Wikipedia

   en.wikipedia.org/wiki/Precursor_B-cell...

   Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma. ALL is the ...