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  2. Huntington's disease - Wikipedia

    en.wikipedia.org/wiki/Huntington's_disease

    Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease [7] that is mostly inherited. [8] The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. [9] [1] A general lack of coordination and an unsteady gait often follow. [2]

  3. Lead time bias - Wikipedia

    en.wikipedia.org/wiki/Lead_time_bias

    No additional life span has been gained, and the patient may even be subject to added anxiety as the patient must live for longer with knowledge of the disease. For example, the genetic disorder Huntington's disease is diagnosed when symptoms appear at around 50, and the person dies at around 65. The typical patient, therefore, lives about 15 ...

  4. List of human disease case fatality rates - Wikipedia

    en.wikipedia.org/wiki/List_of_human_disease_case...

    Human infectious diseases may be characterized by their case fatality rate (CFR), the proportion of people diagnosed with a disease who die from it (cf. mortality rate).It should not be confused with the infection fatality rate (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.

  5. Huntingtin - Wikipedia

    en.wikipedia.org/wiki/Huntingtin

    Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage.

  6. Anticipation (genetics) - Wikipedia

    en.wikipedia.org/wiki/Anticipation_(genetics)

    Once the number of copies reaches over 100, the disease will manifest earlier in life (although the individual will still reach adulthood before the symptoms are evident) and the symptoms will be more severe – including electrical myotonia. As the number progresses upwards past 400, the symptoms show themselves during childhood or infancy.

  7. Huntington's Disease Outreach Project for Education at Stanford

    en.wikipedia.org/wiki/Huntington's_Disease...

    The Huntington's disease Outreach Project for Education at Stanford (HOPES) is a student-run project at Stanford University dedicated to making scientific information about Huntington's disease (HD) more readily accessible to patients and the public.

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  9. Adult development - Wikipedia

    en.wikipedia.org/wiki/Adult_development

    Huntington's disease (HD) named after George Huntington is a disorder that is caused by an inherited defect in a single gene on chromosome 4, resulting in a progressive loss of mental faculties and physical control. [72] [73] HD affects personality, leads to involuntary muscle movements, cognitive impairment, and deterioration of the nervous ...

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