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A review for Boston Magazine called Sinclair "one of science's most controversial figures" and said many in the scientific community were skeptical of claims he made about human longevity. University of Alabama biology professor Steven N. Austad said, "David is a good friend, but I do think he's been guilty of making excessive claims."
David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics.Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.
In 1993, Cynthia Kenyon's lab at UCSF discovered that a single-gene mutation in could double the lifespan of C. elegans. That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of sirtuins. [8]
Lifespan or life span may refer to: Lifespan, 1976 film starring Klaus Kinski; Lifespan, 1983 Atari 8-bit computer game; Lifespan, 2004 album by Kris Davis; Lifespan: Why We Age - and Why We Don't Have To, 2019 book by David Andrew Sinclair; Lifespan.io, non-profit crowdfunding platform of the Lifespan Extension Advocacy Foundation
In 1993, Kenyon's discovery that a single-gene mutation could double the lifespan of C. elegans and that this could be reversed by a second mutation in daf-16m, [4] sparked an intensive study of the molecular biology of aging, including work by Leonard Guarente and David Sinclair. [1]
David Sinclair and Rachel Drake shattered records in winning the men's and women's titles in the 62nd annual JFK 50 Mile ultramarathon on Saturday. Sinclair, 32, of South Burlington, Vermont, took ...
The median "ideal lifespan" was 91 years of age and the majority of the public (63%) viewed medical advances aimed at prolonging life as generally good. 41% of Americans believed that radical life extension (RLE) would be good for society, while 51% said they believed it would be bad for society. [91]
In January, a team led by David Sinclair shows in a 13-year-long international study how DNA breaks or epigenetic damage are a major driver of epigenetic change, and how the loss of epigenetic information is a cause of aging in mammals. It concluded that the loss of epigenetic information can drive aging independently of changes to the genetic ...
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