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DESeq2 is a software package in the field of bioinformatics and computational biology for the statistical programming language R. It is primarily employed for the analysis of high-throughput RNA sequencing (RNA-seq) data to identify differentially expressed genes between different experimental conditions.
Using DESeq2 as a framework, DEvis provides a wide variety of tools for data manipulation, visualization, and project management. DEXSeq is Bioconductor package that finds differential differential exon usage based on RNA-Seq exon counts between samples. DEXSeq employs negative binomial distribution, provides options to visualization and ...
RNA selection/depletion: To analyze signals of interest, the isolated RNA can either be kept as is, enriched for RNA with 3' polyadenylated (poly(A)) tails to include only eukaryotic mRNA, depleted of ribosomal RNA (rRNA), and/or filtered for RNA that binds specific sequences (RNA selection and depletion methods table, below). RNA molecules ...
Within computational biology, an MA plot is an application of a Bland–Altman plot for visual representation of genomic data. The plot visualizes the differences between measurements taken in two samples, by transforming the data onto M (log ratio) and A (mean average) scales, then plotting these values.
Origin is primarily a GUI software with a spreadsheet front end. Unlike popular spreadsheets like Excel, Origin's worksheet is column oriented. Each column has associated attributes like name, units and other user definable labels. Instead of cell formula, Origin uses column formula for calculations.
In another usage in statistics, normalization refers to the creation of shifted and scaled versions of statistics, where the intention is that these normalized values allow the comparison of corresponding normalized values for different datasets in a way that eliminates the effects of certain gross influences, as in an anomaly time series. Some ...
The quality of the data should be checked as early as possible. Data quality can be assessed in several ways, using different types of analysis: frequency counts, descriptive statistics (mean, standard deviation, median), normality (skewness, kurtosis, frequency histograms), normal imputation is needed. [111]
Denormalization is a strategy used on a previously-normalized database to increase performance. In computing, denormalization is the process of trying to improve the read performance of a database, at the expense of losing some write performance, by adding redundant copies of data or by grouping data.