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A depiction of Two-Pore Channel 2 (TPC2). There are two domains, labelled I and II. A pore exists in each domain, as labeled by P. Adapted from image in Grimm, C. et al. "Role Of TRPML And Two-Pore Channels In Endolysosomal Cation Homeostasis". Journal of Pharmacology and Experimental Therapeutics 342.2 (2012): 236–244. Web.
Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene. [5] TPC2 is an ion channel , however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).
N-type calcium channels, also called Ca v 2.2 channels, are voltage gated calcium channels that are localized primarily on the nerve terminals and dendrites as well as neuroendocrine cells. [1] The calcium N-channel consists of several subunits: the primary subunit α1B and the auxiliary subunits α2δ and β.
Ca v 2.2 : α 2 δ/β 1, β 3, β 4, possibly γ: Throughout the brain and peripheral nervous system. P-type calcium channel ("Purkinje") /Q-type calcium channel: HVA (high voltage activated) Ca v 2.1 : α 2 δ, β, possibly γ: Purkinje neurons in the cerebellum / Cerebellar granule cells: R-type calcium channel ("Residual") intermediate ...
A lich's most often depicted distinguishing feature from other undead in fantasy fiction is the method of achieving immortality; liches give up their souls to form "soul-artifacts" (called a "soul gem" or "phylactery" in other fantasy works), the source of their magic and immortality. Many liches take precautions to hide and/or safeguard one or ...
PP 2.0 centers around the universal human capacity for meaning-seeking and meaning-making [10] in achieving optimal human functioning under both desirable and undesirable conditions. [2] [11] This emerging movement is a response to perceived problems of what some have called "positive psychology as usual". [5]
A channel that is "inwardly-rectifying" is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell). It is thought that this current may play an important role in regulating neuronal activity, by helping to stabilize the resting membrane potential of the cell.
Single channel data from cardiomyocytes have shown that protons can decrease the conductance of individual sodium channels. [51] The sodium channel selectivity filter is composed of a single residue in each of the four pore-loops of the four functional domains. These four residues are known as the DEKA motif. [52]