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The lacrimal gland is a compound tubuloacinar gland, it is made up of many lobules separated by connective tissue, each lobule contains many acini.The acini composed of large serous cells which, produce a watery serous secretion, serous cells are filled with lightly stained secretory granules and surrounded by well-developed myoepithelial cells and a sparse, vascular stroma.
Lacritin is a glycoprotein of the human tear film, and to a lesser extent of saliva, lung lavage [27] and plasma. [28] It is mainly produced by the lacrimal gland. [4] Some lacritin also is produced by the meibomian gland, and also by epithelial cells of the conjunctiva and cornea. [11]
The lacrimal glands secrete lacrimal fluid, which flows through the main excretory ducts into the space between the eyeball and the lids. [10] When the eyes blink, the lacrimal fluid is spread across the surface of the eye. [10] Lacrimal fluid gathers in the lacrimal lake which is found in the medial part of
Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
Sjögren's disease (SjD) [8] [9] (previously known as Sjögren syndrome or Sjögren's syndrome (SjS, SS)) is a long-term autoimmune disease that primarily affects the body's exocrine glands, particularly the lacrimal and salivary glands.
Respiratory tract, submandibular glands, endocervix MUC6: Y 11p15.5 169 Stomach, ileum, gall bladder, endocervix, endometrium MUC19 Y 12q12 19 corneal and conjunctival epithelia; lacrimal gland [12] MUC7: N 4q13–q21 23 Sublingual and submandibular glands MUC8 N 12q24.3 13/41 Respiratory tract, uterus, endocervix, endometrium MUC9: N 1p13 15 ...
Like the main lacrimal gland, the accessory lacrimal glands are also densely innervated, but they lack parasympathetic innervation. These glands are exocrine glands, responsible for the basal (unstimulated) secretion of the middle aqueous layer of the tear film. [3] 20 to 40 glands of Krause are found in the upper fornix, and 6-8 glands appear ...
GDF15 is being evaluated as a therapeutic target for treatment of cancer cachexia. In September 2024, Pfizer disclosed that the anti-GDF15 monoclonal antibody ponsegromab led to significant increases in body weight in patients with non-small cell lung cancer, pancreatic cancer, and colorectal cancer.